In addition, the study demonstrated that WT HCMV infection of a human glioblastoma cell line (U373) induces VEGF expression while a pUS28 deletion mutant of HCMV fails to induce VEGF upregulation in glioblastoma cells [10] implicating pUS28 signaling in glioma pathogenesis. The gene discussed is VEGFA; the disease is central nervous system cancer.