On the other hand, we are cautious to claim conclusively the specific associations between HLA-A*02:07 and arthritis or between HLA-A*30:04 and genital ulcers and a positive pathergy test, because patients without these clinical manifestations showed higher phenotypic frequencies of HLA-A*02:07 or A*30:04 than controls (Table 4). This evidence concerns the gene HLA-A and arthritic joint disease.