APEX1 and cancer: In two studies comprising a total of 1072 lung cancer patients and 1064 cancer-free controls in Chinese populations, Lu et al. [29] at nearly the same time reported that the similar protective effect of the APE1/Ref-1 -141GG genotype against lung cancer risk, particularly among old subjects, current smokers, and subjects with a positive family history of cancer in their first-degree relatives.