The objective of the current longitudinal investigation was therefore to evaluate the impact of PTPN22 on disease progression as assessed by liquid meal-stimulated C-peptide and proinsulin, HbA1c, daily insulin dose, insulin dose-adjusted HbA1c (IDAA1C) [13], antibodies to the protein tyrosine phosphatase related IA-2 molecule (IA-2A), islet cell antibodies (ICA), insulin antibodies (IA), glutamic acid decarboxylase antibodies (GADA) and zinc transporter-8 antibodies (ZnT8Ab) in the Hvidoere Study Group on Childhood Diabetes (HSG) remission phase cohort [14]. This evidence concerns the gene INS and diabetes mellitus.