Aberrant activation of mTOR, an important serine/threonine protein kinase involved in protein translation, cellular proliferation, cellular motility, and cellular survival,[11] promotes the growth of malignant tumors such as glioblastoma multiforme;[17] however, a role for this pathway in the proliferation and survival of benign pituitary adenoma cells remained unknown. This evidence concerns the gene AKT1 and glioblastoma.