TF and cancer: Given that TF was detected on angiogenic VECs in cancer (Contrino et al, 1996; Hu et al, 1999; Hu and Garen, 2001; Tang et al, 2007; Cocco et al, 2010) and other pathological neovasculature-involved diseases such as wMD (Bora et al, 2003; Tezel et al, 2007) and endometriosis (Krikun et al, 2010), Icon immunotherapy was effective and safe for the treatment of cancer (Hu et al, 1999; Hu and Garen, 2000, 2001; Tang et al, 2007; Cocco et al, 2010), wMD (Bora et al, 2003; Tezel et al, 2007) and endometriosis (Krikun et al, 2010) in preclinical studies.