MLH1 and non-small cell lung carcinoma: 染色体3p区等位基因缺失是肺癌发生中较频繁和早期的事件之一,其中3p12-13、3p14.2、3p21.1-21.2、3p21.3和3p24-26等被证实是缺失的热点区域,提示在这些区域存在多个抑癌基因[2, 3]。本实验以改良的甲基化特异性聚合酶链反应(methylation specific PCR, MSP)检测78例NSCLC组织中3p区抑癌基因DLEC1(deleted in lung and esophageal cancer 1)、RASSF1A(Ras associated domain family member 1)、hMLH1(mutL homolog 1)、RARβ(retinoic acid receptor β)和FHIT(fragile histidine triad gene)的甲基化状况,并分析与临床病理特征的关系。