Transcriptional repression of the E-cadherin gene is emerging as an important mechanism through which E-cadherin is downregulated during tumor progression and such factors as snail, slug/snail2, zinc finger E-box binding homeobox (ZEB) 1 and ZEB2 have been shown to directly bind to the E-cadherin promoter and repress its transcription [15]. This evidence concerns the gene CDH1 and neoplasm.