Histamine induced itch causes a neurogenic inflammation, therefore the mechanisms underlying the inflammatory processes involved in the pathophysiological manifestation of atopic dermatitis (factored into the EASI score) may share a common link with the histamine induced response, while the itch induced via PAR-2 pathway may not, since it does not evoke a neurogenic response [10]. Here, F2RL1 is linked to atopic eczema.