The colon carcinoma cell line inducedmigration of DC in 16 h that was abolished by anti-IL8 neutralizing mAb.Interestingly, if DC had been pre-exposed for 24 h to recombinant IL-8,migration was also abolished indicating that desensitized DC could not migratetowards the IL-8-producing carcinoma cells. The gene discussed is CXCL8; the disease is colon carcinoma.