Among the genes found to be upregulated in cancer cell lines,GBX2 and IPF1 did not exhibit such tendency among clinical breast cancer cases.Among the downregulated genes in cancer cell lines, the correlation was weak withPOU3F1 and CXorf43 (HDX), and a reverse tendency of upregulation was observed withCRX, HOP (HOPX), and IRX4. The gene discussed is IRX4; the disease is cancer.