TP53 and breast cancer: The combined-PI risk predictor for breast cancer specific death was the most significant among all the tested predictors in the univariate setting (likelihood ratio test p = 0.001) with the second largest HR 3.36 (95% CI 1.5—7.4), following TP53 mutation status (HR 3.46 with 95% CI 1.7—7.2; Figure S4B).