To challenge the role of CCD-sIgE in plant food allergy, we chose two different RNAinterference (RNAi) approaches to minimize CCD epitopes in plant-derived foodstuff:i) reduction of single glycoallergen Lyc e 2 in tomato, and ii) reduction of all CCDepitopes in tomato and potato (Figure1A). Here, RUNX2 is linked to food allergy.