TP53 and neoplasm: Assessing the nature of thetumor-suppressor mechanism governed by p53 in this instance of lymphomagenesis isseverely hampered by the fact that a dysplastic, pre-tumorigenic state has not beenidentified in any of the mouse models of ALCL described to date, nor in patients.This is in contrast to the genesis of many solid tumors which can be traced througha series of well-defined histopathological changes in tissue architecture from abenign tumor through to its malignant conversion.