Whilst the p53gene is rarely mutated in ALK+ ALCL [43] - indeedp53 mutations are uncommon in a range of hematopoietic cancers[44] – wehave previously shown that p53 function is disrupted in ALK+ ALCLcell lines through NPM-ALK-mediated p53 degradation in a manner that depends on theactivities of MDM2 and JNK [33]. The gene discussed is MDM2; the disease is anaplastic large cell lymphoma.