The following pathways (together with their respective genes) were the most significantly represented canonical pathways (Fisher's exact test p-value<0.05): myc-mediated apoptosis signaling (FAS↑, SHC1↓ and TP53↓); thyroid cancer signaling (SHC1↓ and TP53↓); fatty acid metabolism (ADHFE1↑, CPT1A↓, CYP51A1↓ and SLC27A6↓); iCOS-iCOSL signaling in T-helper cells (PLEKHA3↑, PPP3CC↑ and SHC1↓); and glycine, serine and threonine metabolism (GNMT↓, SARDH↓ and SMOX↓). The gene discussed is ICOS; the disease is thyroid cancer.