Of the eighteen genes significantly affecting counts of Swollen Joints (SJ), correlative statistical models identified only two transcripts, CTSC and IL32. REFS identified the importance of RUNX1, a transcription factor that regulates genes such as BLK, TCR, CD3 and GM-CSF in lymphoid cells [44] and which may play a role in autoimmune disease such as rheumatoid arthritis [45]. The gene discussed is CTSC; the disease is rheumatoid arthritis.