In addition to the few genes mentioned above, network analysis predicts additional transcripts such as STAT3. STAT3 has been identified as a pro-survival molecule for RA synoviocytes [42], and has also been shown to mediate some of the pro-inflammatory signaling of IL-6 {Hirano, #88} – yet another target of approved RA treatments. Here, IL6 is linked to rheumatoid arthritis.