IFNG and disease arising from reactivation of latent virus: Interestingly, however, in line with our data and a recent study by Casey et al.[21], their results presented indicate that the percentage of IFN-γ/IL-2 double positive T cells was higher in latently infected individuals; in that respect, it would be interesting to comparatively assess sensitivities and specificities for multifunctional and for IFN-γ/IL-2 double positive T cells to distinguish active from latent infection.