TP53 and breast carcinoma: They have found that response to p53 alone was not a significant predictor of breast carcinoma (area under the curve (AUC) = 0.48, P = .538), but combining responses to two antigens (p53 and HER2) resulted in an AUC = 0.61 (P = .006), and combining responses to all of the four antigens increased the AUC to 0.63 (P = .001).