However, mice with one C379A mutant allele on a Cbl-null background (with wild-type Cblb) succumb to myeloid malignancies with a median survival time of 47 weeks [36]; although the disease in these mice develops later than in Cbl, Cblb double-deficient mice [35], the overall features of the disease are remarkably similar. Here, CBL is linked to myeloid neoplasm.