Consistent with the curve generated for the total population, RasGrf1−/− without tumors displayed a 20% increase in average lifespan as compared with tumor-free control mice (mean values WT: 99±4.5 weeks and RasGrf1−/−: 119±4.9; median WT: 102 weeks; RasGrf1−/−: 121 weeks) (p= 0.0003, Logrank test) (Figure 1B). Here, RASGRF1 is linked to neoplasm.