SLC6A5 and hyperekplexia: In addition, we report the underlying genetic cause—a microdeletion in the GlyT2 gene SLC6A5. Consistent with previous reports of GlyT2 mutations in human hyperekplexia (Rees et al., 2006; Eulenburg et al., 2006) and bovine congenital muscular dystonia type 2 (Charlier et al., 2008; Gill et al., 2011), this canine disorder exhibited an autosomal recessive mode of inheritance, consistent with a loss of function of GlyT2.