TRPC6 and familial pancreatic carcinoma: Blockade of TRPC1 and TRPC6 also holds considerable potential in GI oncology, given that TRPC1 may promote pancreatic cancer cell invasion (Dong H. et al., 2010) and TRPC6 seems to play a significant role in human esophageal and gastric cancer development (Cai et al., 2009; Shi et al., 2009).