TRPV1 and irritable bowel syndrome: If these approaches turn out to be successful, TRPV1 blockers may enjoy a wide spectrum of usefulness in GI disease which includes, pain, hyperalgesia and inflammation associated with gastro-esophageal reflux disease, inflammatory bowel disease, functional Gi disorders including functional dyspepsia and irritable bowel syndrome, disturbances of GI motor activity, and nausea and emesis.