Referred hyperalgesia associated with caerulein-induced pancreatitis in mice depends on both protease-activated receptor-2 (PAR-2) and TRPV1, TRPV1 being a downstream transducer of the pronociceptive action of PAR-2 stimulation (Fukushima et al., 2010; Nishimura et al., 2010). This evidence concerns the gene TRPV1 and pancreatitis.