Diseases with defective bone development such as metatropic dysplasia, brachyolmia, spondylo-epiphyseal dysplasia of Kozlowski type, spondylo-epiphyseal dysplasia of Maroteaux type (pseudo-Morquio syndrome type 2) and parastremmatic dysplasia are also associated with TRPV4 channelopathies (Camacho et al., 2010; Loukin et al., 2010; Nishimura G. et al., 2010). The gene discussed is TRPV4; the disease is channelopathy.