Emerging evidence indicates that TRPV1 contributes to pancreatic islet inflammation associated with type I diabetes and, in addition, plays a role in insulin-dependent glucose regulation, type II diabetes, adipogenesis and obesity (Razavi et al., 2006; Gram et al., 2007; Zhang L.L. et al., 2007; Suri & Szallasi, 2008). This evidence concerns the gene INS and type 2 diabetes mellitus.