An implication of TRPC6 in human GI motor control is exemplified by the observation that a single nucleotide polymorphism in the promoter region of the TRPC6 gene and a missense variant in exon 4 of the TRPC6 gene may contribute to infantile hypertrophic pyloric stenosis (Everett et al., in press). This evidence concerns the gene TRPC6 and hypertrophic pyloric stenosis.