While TRPV5 occurs primarily in the kidneys, TRPV6 is predominantly expressed in intestinal epithelial cells and has also been localized to human colon cancer (Caco-2) cells (Schoeber et al., 2007; Fukushima et al., 2009; Bartik et al., 2010). Here, TRPV6 is linked to colonic neoplasm.