High-threshold splanchnic afferents innervating the mesentery and serosa of the colon fail to be sensitized in rats with dextran sulfate sodium (DSS)-induced colitis, yet the response of these fibers to mechanical probing is attenuated by a TRPV1 blocker in inflammation but not health (Phillis et al., 2009). Here, TRPV1 is linked to colitis.