The biomarkers found in heart failure include BNP, NT pro-BNP, C-reactive protein, tumor necrosis factor α, interleukins 1 and 6, TNF-α, matrix metalloproteinases, neuroepinephrine, renin, galectin-3 [16-18], some of which are also important tools in the diagnosis and pathogenesis of heart failure, in the identification of subjects at risk of heart failure, risk stratification, therapeutic agents response monitoring [17]. The gene discussed is TNF; the disease is heart failure.