TNF and fleck corneal dystrophy: Infliximab, a chimeric (75 percent human and 25 percent murine) immunoglobulin G1(IgG1) monoclonal antibody against TNF-a, is the prototype anti-TNF-a agent shown to be efficacious in both the induction and maintenance of fistula closure in approximately two-thirds of patients and has now become the cornerstone of medical therapy for FCD [2].