Although GWAS studies have reported significant associations between rs2075650 and Alzheimer's disease, brain imaging, total cholesterol, and CRP plasma levels (Reiner et al., 2008; Aulchenko et al., 2009; Seshadri et al., 2010; Shen et al., 2010), no analyses were performed to determine whether these associations are APOE independent. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.