The parkinsonism-plus-predominant phenotype is associated with mutations within intron and exon 10, leading to the overproduction of 4R-tau isoforms.[8] FTD linked to chromosome 3 (FTD3) is associated with aberrant splicing of CHMP2B (chromatin-modifying protein 2B) gene. The gene discussed is CHMP2B; the disease is frontotemporal dementia.