APOE and Alzheimer disease: Other minor components were also discovered in plaques such as alpha-1-antichymotrypsin,[35] apolipoprotein E (ApoE),[36] advanced glycation end products,[37] protein kinase C (PKC),[38] fibroblast growth factor,[39] complement,[40] and heparin sulphate glycans.[41] Some of the minor components of the SP such as ApoE have been independently implicated in the pathogenesis of AD.