CYP46A1 and Alzheimer disease: The association of other cholesterol transport and metabolism related genes (e.g., ABCA1, CYP46, SORLA) with AD support this hypothesis.[70–73] Moreover, a high cholesterol diet fosters amyloid deposition in AbPP-PS1 transgenic mice and appears to increase cleavage of APP by BACE-1.[74] Anti-cholesterol medication (statins) use appears to be protective against AD in clinical surveys although it has not been effective in AD treatment.