Elucidation of the temporal sequence of genetic events (e.g. the Ig/c-myc translocation in BL), epigenetic alterations (e.g. stem cell-like epigenetic marks of BL cells) and EBV infection (an early event during the genesis of BL) will be indispensable in case of each EBV positive lymphoma type for a better understanding of lymphoma development and progression. Here, MYC is linked to Burkitt lymphoma.