It is interesting that the discovery that DARC is the receptor for P. vivax on red cells, which led to the discovery of the parasite antigen which interacts with this receptor, has led to the development of at least one promising target for vaccine production.38 It is very important to determine whether there are other lessons of this kind that remain to be learned from a better appreciation of the mechanisms of protection against malaria by other hemoglobin or related red cell polymorphisms. Here, ACKR1 is linked to malaria.