Moreover, administration of high doses of tissue-type plasminogen activator (t-PA) or low doses of plasminogen activator inhibitor-1 (PAI-1)-resistant t-PA prevented fibrin deposition in kidneys of endotoxin-treated rabbits.33 Likewise, in a rat model of endotoxemia, fibrin deposition in lungs was decreased by an inhibitor of PAI-1.33 The gene discussed is SERPINE1; the disease is serum lipopolysaccharide activity.