The diagnosis of DIC is still based on the combination of a typical underlying disease, such as sepsis, with laboratory markers, including platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen concentration, and a fibrin-related marker, reflecting intravascular fibrin formation, such as D-dimer, all of which are used in the DIC scores.11 However, new parameters are being investigated that could be of clinical utility. Here, F2 is linked to Sepsis.