In accordance with the international definitions, they can be identified as: 1) active carriers, in presence of HBeAg or of anti-HBe antibodies and of a viral load ≥ 2–20,000 IU/ml; this condition is associated with the presence of hepatic disease in the most part of cases, or 2) inactive carriers, in case of subjects HBeAg-negative and antiHBe-positive, whose alanine aminotransferase (ALT) levels are persistently within the normal range, HBV DNA below 2,000 IU/ml in the most part of cases and IgM antiHBc levels < 0.20 IMx Index. This evidence concerns the gene GPT and liver disorder.