Thrombocytopenia is defined as a platelet count of 20,000 to < 70,000/mm3 and it is a possible cause of interferon dose reductions in less than 4% of patients on combination therapy.6 It is more severe with PEG-IFN/RBV therapy as compared to non-pegylated IFN/RBV therapy. This evidence concerns the gene IFNA1 and Thrombocytopenia.