In a French retrospective study on the use of growth factors in chronic hepatitis C treatment, EPO-β was the main rHuEPO molecule prescribed in a mean dose of 30.000 U weekly (range 2.000–80.000 U).12 Recently, an anecdotal report has shown that the use of a high dose of EPO-β in an HCV-infected patient with severe RBV-induced anaemia was well-tolerated and allowed PEG-IFN/RBV treatment to be completed, limiting its adverse effects and an optimal viral response to be achieved.59 This evidence concerns the gene IFNA1 and chronic hepatitis C virus infection.