It may be concluded that antitoxic immunity contributes significantly to overall vaccine-induced immune protection in cholera for as long as there are specific antitoxin antibodies (approximately 9 months) whereas longer-term protection is due mainly to antibacterial antibodies produced locally in the gut as a result of infection-induced stimulation of IgA memory cells responding sufficiently rapidly to avert the infection before it causes symptoms. This evidence concerns the gene CD79A and vibrio infectious disease.