Further the results showed that tPA/PAI-1 complex was lower in the T2D without MetS compared to normal (P = 0.04), non-diabetic MetS (P = 0.02) and T2D with MetS (p = 0.001) groups while there were no differences in the tPA/PAI-1 complex between the other groups. This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.