Unlike normal subjects, there was a good correlation between fibrinolytic parameters in T2D, the PAI-1 activity well and positively correlated with its antigen (r2 = 0.70, P = 1.1 × 10-36), and negatively correlated with tPA activity (r2 = -0.32, P = 9.9 × 10-12). This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.