On the other hand, the plasma PAI-1 activity was higher in non-diabetic MetS (P = 3.0 × 10-15, 1.5 × 10-18) and T2D with MetS subjects (P = 9.8 × 10-19, 1.8 × 10-21) compared to normal and T2D without MetS subjects respectively. The gene discussed is SERPINE1; the disease is metabolic syndrome.