The pattern of tPA antigen correlation with tPA/PAI-1 complex among T2D was similar to that in normal subjects, but it was a weak correlation (r2 = -0.20, P = 3.5 × 10-7; r2 = 0.06, P = 7.9 × 10-5). The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.