In general, the plasma levels of PAI-1 activity and tPA antigens were higher in T2D patients compared to normal subjects (P = 1.7 × 10-8, 3.0 × 10-24 respectively) whereas the PAI-1 antigen and tPA activity (P = 0.01, 0.03 respectively) were lower in T2D. The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.