The activity and antigen of PAI-1 associated with increased insulin levels (b = 1.941, P = 1.2 × 10-4; b = 1.614, P = 0.015), insulin resistance (b = 1.393, P = 2.2 × 10-4; b = 1.318, P = 0.007), and decreased insulin sensitivity (b = -1.963, P = 1.1 × 10-4; b = -1.637, P = 0.012). The gene discussed is SERPINE1; the disease is Insulin resistance.