SRF and gastric ulcer: The recurrent bleeding rates of gastric ulcers increased stepwise from 0% in non-co-morbid patients without weak SRF up-regulation, 1.9% in co-morbid patients without weak SRF up-regulation to 5.9% in non-co-morbid patients with weak SRF up-regulation and up to 12.5% in co-morbid patients with weak SRF up-regulation (p = 0.006) (Figure 3).