GLP1R and type 2 diabetes mellitus: Exenatide twice daily (exenatide BID) was the first GLP-1 receptor agonist approved for treatment of hyperglycemia in patients with type 2 diabetes not adequately controlled with diet and exercise, sulfonylurea (SFU), TZD, or metformin (MET; alone, or with an SFU, or TZD).