The majority of such cases (14 of 22, P<0.01) were found in different histotypes of NSCLC (ADC, BAC, SCC) at the Stage I. Also we observed several cases of CHL1 up-regulation in metastatic tumors (stomach, lung, trachea, ovary and uterus, Table 1). The gene discussed is CHL1; the disease is non-small cell lung carcinoma.