Icaritin exhibits many pharmacological and biological activities, such as stimulation of neuronal and cardiac differentiation [8], [9], enhancement of osteoblastic and suppressed osteoclastic differentiation and activity [10], prevention of steroid-associated osteonecrosis [11], inhibition of human prostate carcinoma PC-3 cell growth [12], induction of human prostatic smooth muscle cells apoptosis via ERK1/2 pathway [13], and neuroprotective effects [14]. This evidence concerns the gene MAPK3 and prostate carcinoma.