Our studies therefore highlight a dual role for eHsp90 in transducing signaling via LRP1, while additionally promoting its LRP1 co-receptor functions to modulate EphA2 signaling, Recent reports highlighting the ability of eHsp90-LRP1 to elicit pro-motility function in normal and cancer cells [27], [42] portends a widespread role for this signaling pair in a variety of cancers that express EphA2. This evidence concerns the gene EPHA2 and cancer.