In conclusion, in addition to finding some known variants of MTDH, several novel SNPs of MTDH were discovered in our study that appear to be correlated to breast cancer susceptibility Since MTDH has been demonstrated as a key regulator in the complex network of oncogenic pathways, additional investigations further clarifying the functional role of this gene and its association to breast cancer development and recurrence are needed. The gene discussed is MTDH; the disease is breast carcinoma.