Recent reports indicate that certain miRNAs identified in this CLL signature have prognostic value in CLL [30], [31], [32] Additionally, CLL patients expressing CD38 tend to have higher expression of activated cellular markers, including CD27, CD62L, CD69 and KI-67, and this activation status is correlated with poor clinical outcomes [35], [36]. The gene discussed is MKI67; the disease is B-cell chronic lymphocytic leukemia.