In this study, we analyzed levels of CSF Tf in 99 autopsy confirmed cases of sCJD (CJD+) and 75 cases of dementia of non-CJD origin (CJD-) to evaluate the potential of CSF Tf and its isoforms Tf-1 and Tf-β2 as ‘new’ diagnostic biomarkers of sCJD. Here, GTF2H4 is linked to dementia.