Total Tf (T-Tf (WB)) comprising of Tf-1 and Tf-β2 collectively, and individual subunits i.e. Tf-1 and Tf-β2 individually are decreased in the CSF of CJD+ relative to CJD- cases (Figure 1 A, lanes 1–13). Here, GTF2H4 is linked to Creutzfeldt Jacob disease.