GTF2H4 and Creutzfeldt Jacob disease: Comparison of individual subunits of Tf shows a decrease in CSF Tf-1 by 35% (z = 7.59, p<.001) and Tf-β2 by 61% (z = 6.96, p<.001) in CJD+ relative to CJD- samples (Figure 2 C, E), and a decrease of 28% in Tf-1 (z = 4.44, p<.001) and 59% in Tf-β2 (z = 3.96, p<.001) relative to AD samples (Figure 2 D, F).