Comparison of different biomarkers using Mann-Whitney U test reveals that the new biomarkers T-Tf (WB), Tf-1, and Tf-β2 are more sensitive differentiators of the CJD+ vs. CJD- groups in comparison to the current biomarker T-tau (Table 1, Figures 2 A–F and 3 A, B). Here, TF is linked to Creutzfeldt Jacob disease.