Recently, we have developed a novel synthetic analogue of curcumin, 3,4-difluoro-benzo-curcumin [we named it as Difluorinated-Curcumin or in short CDF [10], [11]], which showed greater bioavailability in pancreatic tissues, and also inhibited cell growth, DNA-binding activity of NF-κB, Akt, COX-2, and the production of PGE2 and VEGF, and caused induction of miR-200 and inactivation of miR-21 in PC cells [12]. Here, NFKB1 is linked to pachyonychia congenita.