Interestingly, some extrahepatic tumours also show upregulation of INHA and/or INHBB. INHBB was upregulated in malignant endometrial tissues (Worbs et al, 2007) and in malignant but not in benign pheochromocytomas (Salmenkivi et al, 2001). The gene discussed is INHBB; the disease is benign adrenal gland pheochromocytoma.