Our laboratory has shown that VEGF can stimulate tumour cell migration and invasion of CRC cells (Fan et al, 2005), and these processes were thought to be mediated through VEGFR-1 as a specific antibody (18F1) to VEGFR-1 blocked VEGF-mediated responses (Fan et al, 2005). The gene discussed is FLT1; the disease is colorectal carcinoma.