VEGFA and neoplasm: However, the real role of PlGF in tumour angiogenesis is still highly debated as recently pointed out by Bais et al (2010) who demonstrated that, independently of the status of the VEGF-A pathway, PlGF does not have a significant role in angiogenesis during primary tumour growth in mice, as proven by the lack of angiogenesis and tumour inhibition by anti-PlGF antibodies.