Autotaxin (ATX), also known as phosphodiesterase-I alpha (PD-I alpha) or ecto-nucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is overexpressed in various tumors, including gastric cancer, ovarian cancer [1], breast cancer [2]. This evidence concerns the gene ENPP2 and breast carcinoma.