Focusing on breast cancer patients (Table 5), 3 prognostic factors remained independently predictive of overall survival: PS >1 (HR = 2.08 [95% CI, 1.30-3.35]), LDH >600 U/L (HR = 2.47 [95% CI, 1.56-3.92]) and IL-6 >8 pg/mL (HR = 1.83 [95% CI, 1.17-2.86]). This evidence concerns the gene IL6 and breast carcinoma.