The authors obtained healthy age-matched donor RPE cells with the wild-type complement factor H (CFH) genotype, and AMD donor RPE cells with the homozygous and heterozygous CFH genotype for culture in isotopically unlabelled and heavy amino acids respectively (13C6-Arg and 13C6, 15N2-Lys). This evidence concerns the gene CFH and age-related macular degeneration.