Multidrug resistance (MDR), which is one of the major causes of clinical drug-therapy failure for epilepsy, was reported to be mediated by P-glycoprotein (P-gp) overexpression, which has been determined in human epileptogenic brain tissue resected during epilepsy surgery and in brain of rats following the prolonged status epileptic insults [3]. This evidence concerns the gene PGP and epilepsy.